Further evidence for the involvement of a hippocampal cGMP/cGMP-dependent protein kinase cascade in memory consolidation.

BERNABEU, R., SCHRODER, N., QUEVEDO, J., CAMMAROTA, M., IZQUIERDO, I. & MEDINA, J.

NEUROREPORT

LIPPINCOTT WILLIAMS & WILKINS

Lugar: Philadelphia; Año: 1997 vol. 8 p. 2221 - 2224

0959-4965

HIPPOCAMPAL cyclic GMP (cGMP) has been recentlypostulated to participate in an early phase of memoryconsolidation of an inhibitory avoidance learning in rats.Here we report on the effects of the intrahippocampalinfusion of a soluble guanylyl cyclase inhibitor (LY83583) in the consolidation of one-trial step-downinhibitory avoidance and on the effect of this task onhippocampal cGMP levels and cGMP-dependent proteinkinase (PKG) activity. Bilateral intrahippocampaladministration of LY 83583 (2.5 mg per side) caused fullamnesia for inhibitory avoidance when given immediately(0 min) after training, but not 30 min post-training.Rats submitted to the inhibitory avoidance task showeda significant increase in both cGMP levels and in PKGactivity in the hippocampus at 0 min after training. Nochanges were observed 30 min after training. These findingsprovide further evidence that the hippocampalcGMP/PKG cascade is involved in the early stages ofmemory formation of an inhibitory avoidance task inrats.