Neurogenesis following brain ischemia

FRANK R. SHARP , JIALING LIU , RAMON BERNABEU

DEVELOPMENTAL BRAIN RESEARCH

Elsevier

Año: 2002 p. 23 - 30

0165-3806

Following 5 or 10 min of global ischemia in the adult gerbil there is a tenfold increase in the birth of new cells in the subgranular zoneof dentate gyrus of the hippocampus as assessed using BrdU incorporation. This begins at 7 days, peaks at 11 days, and decreasesthereafter. Over the next month approximately 25% of the newborn cells disappear. Of the remaining cells, 60% migrate into the granulecell layer where two-thirds become NeuN, calbindin and MAP-2 immunostained neurons. The remaining 40% of the cells migrate into thedentate hilus where 25% of these become GFAP labeled astrocytes. It is proposed that ischemia-induced neurogenesis contributes to therecovery of function, and specifically may serve to improve anterograde and retrograde recent memory function that is lost followingglobal ischemia in animals and man.