. Expression of the UGA4 gene encoding the delta-aminolevulinic and g-aminobutyric acids permease in Saccharomyces cerevisiae is controlled by amino acid-sensing systems

BERMUDEZ MORETTI MARIANA; PERULLINI ANA MERCEDES; BATLLE ALCIRA; CORREA GARCIA SUSANA

ARCHIVES OF MICROBIOLOGY

Springer-Verlag

Lugar: Heidelberg; Año: 2005 vol. 184 p. 137 - 140

0302-8933

In yeasts, several sensing systems localized to the plasma membrane which transduce information regarding the availability and quality of nitrogen and carbon sources and work in parallel with the intracellular nutrient-sensing systems, regulate the expression and activity of proteins involved in nutrient uptake and utilization. The aim of this work was to establish whether the cellular signals triggered by amino acids modify the expression of the UGA4 gene which encodes the d-aminolevulinic (ALA) and c-aminobutyric (GABA) acids permease. In the present paper, we demonstrate that extracellular amino acids regulate UGA4 expression and that this e.ect seems to be mediated by the amino acid sensor complex SPS (SSY1, PTR3, SSY5).