Molecular view of the structural reorganization of water in DPPC multilamellar membranes induced by L-cysteine methyl ester

J. M. ARIAS; M. E. TUTTOLOMONDO; S. B. DIAZ; A. BEN ALTABEF

JOURNAL OF MOLECULAR STRUCTURE

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2018 vol. 1156 p. 360 - 368

0022-2860

In order to study the interaction between L-cysteine methyl ester (CM) andmultilamellar vesicles (MLV´s) of DPPC, an extensive study was made by varioustechniques such as Infrared and Raman spectroscopy and Differential ScanningCalorimetry (DSC).Our results revealed by the different techniques used that CM interacts with the DPPCin the region of the polar head, specifying with the phosphate groups, replacing watermolecules of hydration by modifying the hydration of the polar head.By Infrared spectroscopy and DSC we observed an increase in the main transitiontemperature (Tm) and a gradual loss of the pre-transition (Tp) with the increase of themolar ratio CM:DPPC.Of the analyzed, we can conclude that the interaction of CM with DPPC alters thedegree of hydration of the membrane altering properties of the same as the transitiontemperature.Moreover, the results of the thiol site behavior in CM interacting in the CM / DPPCcomplex will be reveal the possibility of unknown functional roles of the lipidiccomponents of the membrane