INVESTIGADORES
BEN ALTABEF Aida
artículos
Título:
Interaction of S-methyl methanethiosulfonate with DPPC bilayer
Autor/es:
DEFONSI LESTARD, M. E.; DIAZ, S. B. ; TUTTOLOMONDO, M. E.; SÁNCHEZ CORTEZ S.; PUIATTI, M. ; PIERINI, A. B.; BEN ALTABEF, A.
Revista:
SPECTROCHIMICA ACTA A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Editorial:
ELSEVIER
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 97 p. 479 - 489
ISSN:
0584-8539
Resumen:
The present study is a first step towards the investigation of S-methyl methanethiosulfonate (MMTS)
interaction with membrane model systems like liposomes. In this paper, the interaction of MMTS with
dipalmitoylphosphatidylcholine (DPPC) bilayers was studied by FTIR and SERS spectroscopy. Lysolipid
effect on vesicle stability was studied. The results show that MMTS interacts to different extents with
the phosphate and carbonyl groups of membranes in the gel and the liquid crystalline states.
To gain a deeper insight into MMTS properties that may be potentially helpful in the design of new
drugs with therapeutic effects, we performed theoretical studies that may be the basis for the design
of their mode of action.