TOLERANCIA INMUNOLOGICA SISTEMICA INDUCIDA POR VIA ORAL

ISMAEL D. BIANCO, S. F. AUSAR, L. F. CASTAGNA, R. K. MIZUTAMARI, D. M. BELTRAMO Y C. A. LANDA

Inmunopatología Molecular : Nuevas fronteras de la Medicina

Panamericana

Año: 2004; p. 193 - 207

ABSTRACT The most frecuent outcome of the expossure of mucoses to dietary antigens is systemic tolerance. From this comes the concept of orally-induced systemic tolerance as a state of unresponsiveness or hyporesponsiveness to an antigen that has been previously ingested. It has been described that antigen feed can induce anergy, apoptosis or regulatory cells that secrete immunosupressive cytokines. The state of immunological tolerance could modulate or be generated concomitantly to secretory immunological responses with IgA production.  The induction of oral tolerance has been used to suppress or block the development of autoimmune diseases in animals and there are various clinical trials in progress. It has also been used to modulate the immune response to dietary antigens and recently has been postulated that it could be used to prevent the development of pathological responses that occur during infections. Key Words: Oral Tolerance, Autoimmunity, Immunomodulation, Anergy, Clonal Deletion.