Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects

SALVA OSCAR; ALASINO ROXANA; CELIA GILLER; JULIETA BORELLO; DORESKY ALEXIS; KALAYAN GALIA; BELTRAMO, DANTE

PLATELETS

TAYLOR & FRANCIS LTD

Lugar: Londres; Año: 2021

0953-7104

Abstract: We analyze changes in circulating platelets in COVID-19 positive patients who received conventionaltreatment Dexamethasone and Enoxaparin (Dexa-Enoxa) compared to patientstreated with conventional therapy plus nebulization with alkaline hypertonic ibuprofenate(AHI). Results show that after 24 h of nebulization with AHI, circulating platelets shows anincrease about 40% at 24 h and reach 65% at 96 h. In patients with platelets content below200,000 by microliter the increase was 49% and 79% at 24 and 96 h respectively. In patientswith platelets above 200,000 by microliter the increase was 24% and 31% at 24 and 96 h,respectively. The increase of platelets via AHI was similar in both, men and women.To evaluate whether this action of AHI was related to platelets from COVID-19 positive patientsor also for healthy people, two controls were included: one of them with 10 healthy volunteersand another one with COVID-19 positive patients hospitalized and treated only with Dexa-Enoxa. Results show that, in healthy volunteers, the number of circulating platelets remainsunchanged even after 7 days of treatment with AHI. In COVID-19 positive patients treated onlywith Dexa-Enoxa for 4 days, platelets increased only 16%.