INVESTIGADORES
BARI Sara Elizabeth
artículos
Título:
Discrimination of Nitroxyl and Nitric Oxide by Water Soluble Manganese(III) Porphyrins.
Autor/es:
MARTÍ, MARCELO A.; BARI, SARA E.; ESTRIN, DARÍO A.; DOCTOROVICH, FABIO A.
Revista:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Editorial:
American Chemical Society
Referencias:
Lugar: Washington, USA; Año: 2005 vol. 127 p. 4680 - 4684
ISSN:
0002-7863
Resumen:
Abstract:The water-soluble manganese(III) meso-tetrakis ( N-ethylpyridinium-2-yl) porphyrin (MnIIITEPyP)
and manganese(III) meso-(tetrakis(4-sulfonato-phenyl)) porphyrinate (MnIIITPPS) are able to chemically
distinguish between HNO and NO donors, reacting with the former in a fast, efficient, and selective manner
with concomitant formation of the {MnNO}7 complex ( kon(HNO) 105 M-1 s-1), while they are inert or react
very slowly with NO donors. DFT calculations and kinetic data suggest that HNO trapping is operative at
least in the case of MnIIITPPS, while catalytic decomposition of the HNO donors (sodium trioxodinitrate
and toluene sulfohydroxamic acid) seems to be the main pathway for MnIIITEPyP. In the presence of oxygen,
the product MnIITEPyP(NO) oxidizes back to MnIIITEPyP, making it possible to process large ratios of
nitroxyl donor with small amounts of porphyrin.