INVESTIGADORES
ARREGUI Carlos Oscar
artículos
Título:
Protein tyrosine phosphatase PTP1B in cell adhesion and migration.
Autor/es:
ARREGUI, C.O., GONZÁLEZ, A., BURDISSO, J.E., AND GONZÁLEZ WUSENER, A.E.
Revista:
CELL ADHESION AND COMMUNICATION
Editorial:
http://landesbioscience.com/journals/celladhesion
Referencias:
Lugar: Austin; Año: 2013 vol. 7
ISSN:
1061-5385
Resumen:
Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics and organization to support cell movement. The endoplasmic reticulum-bound protein tyrosine phosphatase PTP1B has been implicated as a regulator of cell adhesion and migration. Recent results from our laboratory shade light on potential mechanisms, such as Src/FAK signaling through Rho GTPases and integrin-cytoskeletal coupling.
