Facile approach to prepare antibacterial cellulose-chitosan films for ciprofloxacin sustained release

CACICEDO, MAXIMILIANO L.; GUILHERME PACHECO; ISLAN, GERMÁN A.; ALVAREZ VERA; CASTRO, GUILLERMO R.

Mar del Plata

Simposio; XVI Simposio Latinoamericano de Polímeros (SLAP 2018) y el XIV Congreso Iberoamericano de Polímeros (CIP 2018); 2018

Wound healing processes wake up challenging issues either in clinical and research areas because of the social worldwide impact triggered by the increasing number of patients with chronic wounds, burns, scalds, and ulcers. Among many biopolymers used for wound dressings, Bacterial cellulose (BC) has been intensively studied1. On the other hand, chitosan (Chi) has been widely described as an excellent biomaterial for prevention of infections in wounds 2. In this work, we designed an economic viable, simple and non-toxic procedure for ex situ BC modification with Chi. The antibiotic ciprofloxacin (Cip) was incorporated to attend the demand of an antibacterial effect during the first hours of the wound dressing 3,4. Drug release and antibacterial studies were performed.