INVESTIGADORES
ALVAREZ Vera Alejandra
artículos
Título:
Non-covalently coated biopolymeric nanoparticles for improved tamoxifen delivery
Autor/es:
CHEVALIER, MERARI TUMIN; RESCIGNANO, NICOLETTA; MARTIN-SALDAÑA, SERGIO; GONZÁLEZ-GÓMEZ, ÁLVARO; KENNY, JOSÉ MARIA; SAN ROMÁN, JULIO; MIJANGOS, CARMEN; ÁLVAREZ, VERA ALEJANDRA
Revista:
EUROPEAN POLYMER JOURNAL
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 2017 vol. 95 p. 348 - 357
ISSN:
0014-3057
Resumen:
About one-fifth of cancer patients suffer from breast cancer worldwide. Polymeric nanoparticles play an important role in delivering chemotherapeutic agents in a controlled manner. Polylysine coated tamoxifen loaded poly(lactic-co-glycolic acid) nanoparticles were prepared using a single emulsion technique with subsequent non-covalently surface functionalization in order to improve nanoparticle-cell interaction and hence tamoxifen therapeutic effect. The obtained nanoparticles were fully characterized in terms of their physico-chemical properties as well of their in vitro performance against human breast adenocarcinoma cells. The successful incorporation of tamoxifen within the hydrophobic matrix of nanoparticles is evidenced by a high loading efficiency (86%). Furthermore, ideal size, morphology and hydrodynamic properties are observed being the proposed nanocarrier capable of display a valuable antiproliferative in vitro effect.