INVESTIGADORES
ALVAREZ Luis Ignacio
artículos
Título:
Efficacy and Safety of Albendazole and High-Dose Ivermectin Coadministration in School-Aged Children Infected With Trichuris trichiura in Honduras: A Randomized Controlled Trial
Autor/es:
MATAMOROS, GABRIELA; SÁNCHEZ, ANA; GABRIE, JOSÉ ANTONIO; JUÁREZ, MARISA; CEBALLOS, LAURA; ESCALADA, ANDRÉS; RODRÍGUEZ, CAROL; MARTÍ-SOLER, HELENA; RUEDA, MARÍA MERCEDES; CANALES, MARITZA; LANUSSE, CARLOS; CAJAL, PAMELA; ÁLVAREZ, LUIS; CIMINO, RUBÉN O; KROLEWIECKI, ALEJANDRO
Revista:
CLINICAL INFECTIOUS DISEASES
Editorial:
UNIV CHICAGO PRESS
Referencias:
Año: 2021
ISSN:
1058-4838
Resumen:
BackgroundThe efficacy of currently available anthelminthics against Trichuris trichiura infections issignificatively lower than for other soil-transmitted helminths (STH). The combination ofivermectin (IVM) and albendazole (ALB) has shown significant improvements in efficacy.MethodsSafety and efficacy randomized controlled clinical trial comparing 3 experimental regimensagainst ALB monotherapy for the treatment of T. trichiura infections in northern Honduras.Infected children were randomized to one of the following treatments: (Arm 1) single-doseALB 400 mg; (Arm 2) single-dose ALB 400 mg/IVM 600 μg/kg; (Arm 3) ALB 400 mg for 3consecutive days; or (Arm 4) ALB 400 mg/IVM 600 μg/kg for 3 consecutive days. Efficacywas measured through egg reduction rate (ERR) and cure rate (CR), both assessed 14-21 daysafter treatment using the Kato-Katz method. Safety was evaluated by analyzing the frequencyand severity of adverse events.ResultsA total of 176 children were randomized to one of the 4 treatment arms, 117 completedtreatment and follow-up. The ERR for Arms 1 to 4 were: 47.7%, 96.7%, 72.1% and 100%,respectively; with p-values