INVESTIGADORES
ALVAREZ Luis Ignacio
artículos
Título:
Flubendazole in cystic echinococcosis therapy: pharmaco-parasitological evaluation in mice
Autor/es:
CEBALLOS, L.; ELISSONDO, M.; SÁNCHEZ BRUNI, S.; DENEGRI, G.; ALVAREZ, L.; LANUSSE, C.
Revista:
PARASITOLOGY INTERNATIONAL
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Año: 2009 vol. 58 p. 354 - 358
ISSN:
1383-5769
Resumen:
Cystic echinococcosis (CE) caused by the parasite Echinococcus
granulosus is an important public health problem worldwide. Flubendazole
has shown poor in vivo efficacy
against CE in humans and mice. However, flubendazole causes marked in vitro
damage on E. granulosus protoscoleces. The
goals of the current work were: a) to compare the plasma pharmacokinetic
behaviour of flubendazole
formulated as a hydroxipropyl-β-cyclodextrin aqueous solution or as a
carboxymethylcelullose suspension, both given by the oral route to mice, b) to
compare flubendazole clinical efficacy in secondary CE in mice after its
administration as both formulations, c) to evaluate the flubendazole-induced
morphological changes in hydatid cysts recovered from infected mice treated
with both drug formulations.
Flubendazole administration as a solution resulted in significantly
higher plasma maximum concentration (Cmax) and area under the
concentration-time curve (AUC) values compared to those obtained after the
flubendazole-suspension treatment. This enhanced drug availability correlated
with an increased efficacy against secondary CE in mice observed for the
flubendazole-solution formulation, while the suspension formulation did not
reach differences with the untreated control group. Similar ultrastructural
changes were observed in cysts
recovered from flubendazole (both formulations) treated mice after 3, 6 and 9
months of infection, although the damage extension was greater after treatment
with the flubendazole-solution formulation.