Assessment of serum pharmacokinetics and urinary excretion of albendazole and its metabolites in human volunteers

CEBALLOS, LAURA; KROLEWIECKI, ALEJANDRO; JUÁREZ, MARISA; MORENO, LAURA; SCHAER, FABIAN; ALVAREZ, LUIS I.; CIMINO, RUBÉN; WALSON, JUDD; LANUSSE, CARLOS E.

PLOS NEGLECTED TROPICAL DISEASES

PUBLIC LIBRARY SCIENCE

Año: 2018 vol. 12

1935-2735

Soil Transmitted Helminth (STH) infections negatively impact physical and mental development in human populations. Current WHO guidelines recommend morbidity control of theseinfections through mass drug administration (MDA) using albendazole (ABZ) or mebendazole. Despite major reductions in STH associated morbidity globally, not all programs havedemonstrated the expected impact on prevalence of parasite infections. These therapeuticfailures may be related to poor programmatic coverage, suboptimal adherence or the exposure of parasites to sub-therapeutic drug concentrations. As part of the DeWorm3 project,we sought to characterize the serum disposition kinetics and pattern of urinary excretion ofABZ and its main metabolites ABZ sulphoxide (ABZSO) and ABZ sulphone (ABZSO2) inhumans, and the assessment of the duration and optimal time point where ABZ and/or itsmetabolites can be measured in urine as an indirect assessment of an individual?s adherence to treatment