Basic and clinical pharmacology contribution to extend anthelmintic molecules lifespan

LANUSSE, C., LIFSCHITZ, A., ALVAREZ, L.

VETERINARY PARASITOLOGY

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2015 vol. 212 p. 35 - 46

0304-4017

The correct use of pharmacology-based information is critical to design successful strategies for the futureof parasite control in livestock animals. Integrated pharmaco-parasitological research approaches havegreatly contributed to optimize drug activity. In an attempt to manage drug resistance in helminths ofruminants, combinations of two or more anthelmintics are being used or promoted, based on the factthat individual worms may have a lower degree of resistance to a multiple component formulation,when each chemical has a different mode of action compared to that observed when a single compoundis used. However, as emphasized in the current review, the occurrence of potential pharmacokineticand/or pharmacodynamic interactions between drug components highlights the need for deeper andintegrated research to identify the advantages or disadvantages associated with the use of combineddrug preparations. This review article provides integrated pharmacokinetic/pharmacodynamic and clinicalpharmacology information pertinent to preserve the traditional and modern active ingredients aspractical tools for parasite control. Novel pharmacological data on derquantel and monepantel, as representativesof modern anthelmintics for use in livestock, is summarized here. The article also summarizesthe pharmaco-parasitological knowledge considered critical to secure and/or extend the lifespan of therecently available novel molecules.