ALVAREZ Luis Ignacio
Pharmacological knowledge and sustainable anthelmintic therapy in ruminants.
LANUSSE, C., ALVAREZ, L., LIFSCHITZ, A.
ELSEVIER SCIENCE BV
Lugar: Amsterdam; Año: 2013
tConsidering the increasing concern for the development of anthelmintic resistance, theuse of pharmacology-based information is critical to design successful strategies for thefuture of parasite control in livestock. Integrated evaluation of the available knowledge onpharmacological features is required to optimize the activity and to achieve sustainableuse of the existing anthelmintic drugs. The assessment of the drug disposition in the hostand the comprehension of the mechanisms of drug influx/efflux/detoxification in differenttarget helminths, has signified a relevant progress on the understanding of the pharmacol-ogy of anthelmintic drugs in ruminant species. However, additional scientific knowledgeon how to improve the use of available and novel molecules is required to avoid/delayresistance development. Different pharmacokinetic-based approaches to enhance parasiteexposure and the use of mixtures of drugs from different chemical families have been pro-posed as valid strategies to delay the development of anthelmintic resistance. The rationalebehind using drug combinations is based on the fact that individual worms may have alower degree of resistance to a multiple component formulation (each chemical with dif-ferent mode of action/resistance) compared to that observed when a single anthelminticis used. However, the limited available information is unclear on the potential additive orsynergistic effects occurring after co-administration of two (or more) drugs with differentmode of action. This review article contributes to the topic with some pharmacology-baseddata emerging from the assessment of combined anthelmintic preparations. The activityagainst multi-drug-resistant isolates based on novel modes of action is a highly favorableelement to judge the future of some of the recently developed anthelmintic compounds.More specific knowledge on the basic host?parasite kinetic behavior as well as a highlyresponsible use of those novel compounds will be necessary to secure their maximum lifes-pans. Overall, the outcome from integrated pharmaco-parasitological research approacheshas greatly contributed to optimize drug activity, which seems relevant to preserve exist-ing and particularly novel active ingredients as useful tools for parasite control in livestockanimals.