ALVAREZ Luis Ignacio
Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.
ALVAREZ, L., SAUMELL, C., FUSÉ, L., MORENO, L., CEBALLOS, L., DOMINGUE, G., DONADEU, M., DUNGU, B., LANUSSE, C.
ELSEVIER SCIENCE BV
Lugar: Amsterdam; Año: 2013 vol. 194 p. 70 - 74
The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six (36) local ecotype piglets were divided into three independent experiments, named Experiment I, II and III (n= 12 each), respectively. Each experiment involved two different groups (n= 6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Exp. I, II and III), Oesophagostomum spp. (Exp. I and II), T. suis (Experiment II and III) and Metastrongylus spp. (Exp. I). Pigs in the treated group received OFZ (Synanthic®, Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post-treatment, animals were sacrificed and the clinical efficacy of the OFZ treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, OFZ orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp..