ALVAREZ Luis Ignacio
Nematodicidal activity of flubendazole and its reduced metabolite on a murine model of Trichinella spiralis infection.
URBIZU, L.; CONFALONIERI, A.; SÁNCHEZ BRUNI, S.; LANUSSE, C.; ALVAREZ, L.
Lugar: Basel; Año: 2012 p. 1 - 6
Background: Flubendazole (FLBZ) is a broad-spectrum benzimidazole antihelmintic compound. The parent FLBZ is metabolized to its reduced (R-FLBZ) and hydrolyzed (H-FLBZ) metabolites. There are no data on the potential nematodicidal activity of R-FLBZ, the main plasma metabolite found in sheep. The goal of the current work was to assess the efficacy of FLBZ and R-FLBZ against Trichinella spiralis in a mouse model. Methods: Both compounds were administered to Balb/c mice infected with T. spiralis as either a cyclodextrin aqueous solution or as a carboxymethylcelullose suspension. Treatments were performed orally (5 mg/kg) at one day after infection with T. spiralis. The efficacy of the treatments was assessed at day 6 post infection. Results: While the efficacy obtained for FLBZ and R-FLBZ administered as a solution was 94 and 98%, respectively, the efficacies obtained after the treatment with FLBZ suspensions were 38% (FLBZ) and 64% (R-FLBZ). Conclusion: Under the current experimental conditions, a high efficacy of both, FLBZ and R-FLBZ administered as solution preparations was observed. The lower dissolution of both, FLBZ and R-FLBZ, after its oral administration as a suspension, accounts for the low efficacy of both molecules against T. spiralis in mice.