INVESTIGADORES
ALVAREZ Luis Ignacio
artículos
Título:
Residual concentrations of the flukicidal compound triclabendazole in dairy cows milk and cheese.
Autor/es:
IMPERIALE, F.; ORTIZ, P.; CABRERA, M; FARIAS, C.; SALLOVITZ, J.; IEZZI, S.; PEREZ, J.; ALVAREZ, L.; LANUSSE, C.
Revista:
FOOD ADDITIVES AND CONTAMINANTS
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Londres; Año: 2011 vol. 28 p. 434 - 445
ISSN:
0265-203X
Resumen:
Triclabendazole (TCBZ) is a flukicidal halogenated benzimidazole compound extensively used in veterinary
medicine. Liver fluke control in lactating dairy cattle is difficult because treatment should be implemented only
during the dry period to avoid milk residues. However, control in endemic areas is usually implemented as regular
treatments three to four times a year, even during the lactating period. Thus, information on TCBZ milk
excretion and the risk of the presence of drug residues in fluid milk and milk-derivate products is essential. The
experimental aims were to evaluate the comparative disposition kinetics of TCBZ and its sulpho-metabolites
in plasma and milk in lactating dairy cattle after the oral administration (12 mgkg1) of TCBZ and to assess the
pattern of residues in cheese made with milk from treated dairy cows. Both TCBZ sulphoxide and sulphone
metabolites but not TCBZ were detected in milk (up to 36 and 144 h, respectively) and plasma (up to 144 h) after
oral administration of TCBZ. Residual concentrations of TCBZ sulpho-metabolites were found in cheese made
with milk from treated animals. The total average residual concentration in fresh cheese was 13.0-fold higher than
that obtained in milk used for its elaboration. The high concentrations of TCBZ sulpho-metabolites recovered in
fresh cheese should be seriously considered before milk from treated cows is used for making dairy products.