Withanolides from Jaborosa reflexa

MANUELA E. GARCÍA; VIVIANA E. NICOTRA; GERARDO BURTON; JUAN C. OBERTI

Venecia

Otro; 10th Summer School on Green Chemistry; 2008

• Interuniversity National Consortium "Chemistry for the Environment" (INCA)

As part of a project aimed at the search of withanolides with potential application as friendly environmentally herbicides, we report the phytotoxic activity of the main compound from J. reflexa, related structurally to Jaborosalactona 38 isolated from J. caulescens.Compound I was tested on seed germination and radicle length on both a dicotyledon (Lactuca sativa) and a monocotyledon (Avena sativa) as standard target species in the range concentration 15-400 ppm. This metabolite produce a significant inhibition of radicle growth at 150 ppm on Lactuca sativa (41 %), while on Avena sativa the corresponding inhibition was quite small (6%). Dependency of the inhibiting activity with the concentration is not observed. Similar selective inhibition effect on dicotyledon species was reported for Jaborosalactona 38