Withanolides from Three Species of the Genus Deprea (Solanaceae). Chemotaxonomical considerations.

CASERO, C.; OBERTI, J. C. ; OROZCO, C. I.; ALEJANDRO CÁRDENAS; IVÁN BRITO; GLORIA E. BARBOZA; NICOTRA, V. E.

PHYTOCHEMISTRY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2015 vol. 110 p. 83 - 90

0031-9422

Nine withanolides were isolated from the aerial parts of Deprea bitteriana, D. cuyacensis, and D. zamorae. Deprea bitteriana yielded two withaphysalins, D. cuyacensis gave two 13,14-seco withaphysalins, while D. zamorae yielded five physangulidins. New compounds were fully characterized by a combination of spectroscopic methods (1D and 2D NMR and MS). All compounds isolated from Deprea bitteriana and D. cuyacensis were obtained as epimeric mixtures at C-18. The structure of the physangulidin D was confirmed by X-ray diffraction analysis. The skeletons found in this research support the taxonomical position of the genus Deprea in the tribe Physalideae.