Withanolides with Phytotoxic Activity from Two Species of the 2 Genus Salpichroa: S. origanifolia and S. tristis var. lehmannii

VIVIANA NICOTRA; ANA V. BASSO; ROSANA I. MISICO

JOURNAL OF NATURAL PRODUCTS

AMER CHEMICAL SOC

Lugar: Washington; Año: 2013 vol. 76 p. 2219 - 2225

0163-3864

Seven new withanolides, salpichrolides O-U (1-7), the known 2,3-dihydrosalpichrolide B (9), a substance not 10 previously isolated from a natural source, and three known compounds, salpichrolide D (8), salpichrolide A (10), and 11 salpichrolide C (11), were isolated and characterized from the aerial parts of Salpichroa origanifolia and S. tristis var. lehmannii. 12 Compounds 1-4 and 8 have an oxygenated D ring, while compounds 5-7 and 9-11 possess a six-membered aromatic D ring. The structures of the isolated compounds were identified by analysis of their spectroscopic data including NMR and MS. Withanolides 1, 3, 8, 10, and 11 exhibited selective radicle growth inhibition toward Lactuca sativa (lettuce) at 150 and 400 ppm.