INVESTIGADORES
NICOTRA Viviana Estela
artículos
Título:
Antiproliferative activity of withanolides against human breast cancer cell lines
Autor/es:
RUBÉN P. MACHÍN; ADRIANA S. VELEIRO; VIVIANA E. NICOTRA; JUAN C. OBERTI; JOSÉ M. PADRÓN
Revista:
JOURNAL OF NATURAL PRODUCTS
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2010 vol. 73 p. 966 - 968
ISSN:
0163-3864
Resumen:
The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI50 values in the range 0.16-0.71 μM. The aromatic withanolide 19 exhibited specific activity for the estrogenreceptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.