Diuretic activity of Jodina rhombifolia aerial parts on Wistar rats

BAZAN, CRISTIAN ROBERTO; MAURICIO R TEVES; PABLO PACHECO; GRACIELA H. WEDEL

Journal of Pharmacy & Pharmacognosy Research

JPPRes

Lugar: Antofagasta; Año: 2018 vol. 6 p. 402 - 414

0719-4250

Abstract Context: Jodina rhombifolia (Hook. & Arn.) Reissek (Santalaceae) it´s usedin folk medicine for treat a great diversity of health problems.Aims: To evaluate the diuretic activity of aerial parts methanolic extract(leaves, bark, phloem, and branches of approximately three years) inWistar rats.Methods: The experimentation was organized with a negative controlgroup (saline solution), a positive control (furosemide; 10 mg/kg) andfor each methanolic extract were established three groups of animalsthat received doses of 125, 250 and 500 mg/kg of weight in normalsaline solution.Results: The maximum diuretic activity observed in-group administeredwith leaves methanolic extract followed of phloem extract. The dose 250mg/kg of leaves methanolic extract was the more potent and equallyimportant, result the dose 500 mg/kg, which supposes aninteresting excretor effect of water for a phytodiuretic. These registers ofdiuresis in Wistar rats did not show significant statistically results withthe positive control group. Furthermore, the onset of diuretic activity ofleaves methanolic extract was extremely rapid, within the first hour ofadministration (for all doses).Conclusions: This study contribute to scientific validation of theethnomedical use of this botanic species in folk medicine of SouthAmerica as diuretic agent, although further studies are necessary toevaluate the mechanisms involved in biological activity and safetyfollowing repeated use.