INVESTIGADORES
FREUDENTHAL Ramiro A. M.
congresos y reuniones científicas
Título:
Protein acetylation and synaptic composition during Inhibitory Avoidance Long-Term memory consolidation in mouse hippocampus
Autor/es:
LAURA ESQUIVEL; ANGELES SALLES; JULIA BUSSO; MARÍA KRAWCZYK; MARIANO BOCCIA; RAMIRO FREUDENTHAL
Lugar:
Berlin
Reunión:
Congreso; Fens 2018; 2018
Institución organizadora:
Federation of European Neuroscience Societies
Resumen:
Protein acetylation affects synaptic plasticity and memory, but its effects on synapse composition ?in vivo? during longterm memory consolidation have not been addressed. Here we show that there is a correlation between the synapticprotein acetylation level and the synaptic protein composition at hippocampus during memory consolidation. We alsoshow that altering the acetylation levels by administration of a Lysine deacetylase inhibitor specific for KDAC6 (mainlycytoplasmic) immediately after training facilitates retention at testing. These results suggest that the post translationmodification, lysine acetylation, has a role regulating the synaptic changes that occur during memory consolidation.
