Effect of chia oil in body weight and carbohydrate metabolism in rabbits

LILIANA SIERRA; ANALIA MEDINA; MIRTA MEDINA; GABRIELA ALARCÓN; JULIETA ROCO; SUSANA JEREZ

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Excessive fat intake is associated with increase of cardiovascular risk factors. Data from the literature indicate that high carbohydrate or fat diet increases body weight (BW), fasting glucose, insulin levels and induces glucose intolerance (GI). In previous work we demonstrate that diet supplemented with 10% chia oil has beneficial effects on vascular function in spite of inducing GI. The objective of this work was to analyze the effect of reducing % of chia oil in endothelial function, biochemical and hemodynamic parameters. Rabbits were fed either a control diet (CD), CD enriched with 3% chía oil (CD-Ch 3%), or a CD enriched with 10% chia oil (CD-Ch 10%) for 6 weeks. Blood pressure (BP), heart rate (HR), glucose tolerance, total cholesterol (CT), HDL, LDL, and triglycerides (TG) parameters were determined. The endothelial function was evaluated in aortic rings contracted with phenylephrine (Phe) 5.10-6 M and exposed to acetylcholine (Ach, 10-8 M to 5.10-6 M). Rabbits fed a-Ch 3% showed: 1) decrease of BW (CD: 1876±238g; CD-Ch 3%: 1526±25g; CD-Ch10%: p