INVESTIGADORES
JEREZ Susana Josefina
artículos
Título:
Partial replacement of corn oil with chia oil into a high fat diet produces either beneficial and deleterious effects on metabolic and vascular alterations in rabbits
Autor/es:
ALARCĂ“N, GABRIELA; MEDINA, ANALIA; MARTIN ALZOGARAY, FLORENCIA; SIERRA, LILIANA; ROCO, JULIETA; VANNIEUWENHOVE, CARINA; MEDINA, MIRTA; JEREZ, SUSANA
Revista:
Pharmanutrition
Editorial:
Elsevier
Referencias:
Año: 2020
ISSN:
2213-4344
Resumen:
Background: the beneficial effects of Salvia hispanica (chia) seed on metabolicparameters have been widely studied. However, there are little evidence about theeffects of chia seed oil (ChO) on metabolic syndrome (MS). Thus, we aimed toevaluate the isocaloric partial replacement of corn oil with ChO into a high fat diet onmetabolic parameters and vascular alterations in a model of MS. Methods: rabbitswere fed either regular diet (CD); CD supplemented with 3% ChO (CD-Ch); CDsupplemented with 8% lard and 10% corn oil (HFD) or HFD in which 3% of corn oil wasreplaced with ChO (HFD-Ch), for 6 weeks. Results: HFD-Ch reduced the HFD-inducedrise of triacylglycerol and n-6/n-3 fatty acids ratio. However, the deleterious effect ofHFD on fasting glucose (FG), abdominal obesity and glucose tolerance was worsened.Reduction of palmitoleic acid level in plasma from HFD-Ch may account for worseningof FG. HFD-Ch reversed the HFD-induced endothelial dysfunction and sensitized aortictissues to angiotensin II. Mechanism of such phenomenon may involve the lowestincrease of linolenic acid levels in erythrocyte membranes from HFD-Ch compared toCD-Ch. Conclusion: partial replacement of corn oil with ChO into HFD produced bothbeneficial and harmful effects on MS