JEREZ Susana Josefina
Dieta Rica en grasas y esteatosis microvesicular
SOFIA KARBINER; FRANCO PUCCI ALCAIDE; SUSANA JEREZ
Investigación en Salud
Ministerio de Salud Pública de Tucumán
Lugar: Tucumán; Año: 2018 vol. 1 p. 16 - 21
High fat diet induces non-alcoholic fatty liver disease that is now considered to be the hepatic component of the metabolic syndrome. The present study was carried out to evaluate morphological changes in the liver and its association with known biomarkers of metabolic disease: insulin resistance, triglyceride levels, oxidative stress and omega n-6/omega n-3 fatty acid ratio in a model of high fat diet induced- metabolic syndrome. Animals were fed either on regular chow or high fat diet 10 %. After 12 weeks, body weight, visceral abdominal fat, glucose tolerance test, mean arterial blood pressure and heart rate were significantly increased in rabbits fed on high fat diet. Plasma levels of total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, glutathione reduced/glutathione oxidized ratio and thiobarbituric acid reactive substances were similar in both diet groups. Insulin from plasma and omega n-6/omega n-3 fatty acid ratio from plasma and from liver were higher in rabbis fed on high fat diet. Histological analysis showed hepatic microvesicular steatosis in this obesity model. In conclusion, high fat diet induced together with metabolic alterations characterizing the metabolic syndrome early liver injury compatible with microvesicular steatosis and increased omega n-6/omega n-3 fatty acid ratio. Considering that in such conditions triglycerides levels and oxidative parameters were similar to controls, omega n-6/omega n-3 fatty acid ratio may be the earlier biomarker of liver injury in the metabolic syndrome.