Competitive exclusion between non-pathogenic type A and type E strains of Clostridium perfringens

REDONDO L.; PEREYRA A.; DOMINGUEZ J.; FERNANDEZ MIYAKAWA ME

Congreso; Clostpath 2013; 2013

Clostridium perfringens (CP) type E causes hemorrhagic enteritis and sudden death in cattle. By definition, it produces alpha and iota toxin (ITX), a binary toxin which induces the disruption of the cytoskeletal architecture. The mechanism by which type E strains produces disease and the role of ITX remains unclear. Previous works with ITX and CDT, suggest that this group of toxins would increase the adherence of C. difficile cells to enterocytes. In natural cases of cattle type E enteritis, MLST studies shows a clonal predominance, suggesting that type E strains could displace other CP strains. Intra-specific growth inhibition was proposed as a virulence trait in avian necrotic enteritis type A strains, but there are no reports of this in cattle.