INVESTIGADORES
LONGHI Marcela Raquel
artículos
Título:
Simultaneous improvement of ketoconazole solubility, antifungal and antibiofilm activity by multicomponent complexation
Autor/es:
A. ZOPPI; A. BARTOLILLA; M. LONGHI; V. AIASSA
Revista:
Therapeutic Delivery
Editorial:
Future Science
Referencias:
Lugar: London; Año: 2021 p. 1 - 12
ISSN:
2041-5990
Resumen:
A novel multicomponent complex (MC) of ketoconazole (KET) with β-cyclodextrin (β-CD)and N-acetylcysteine (NAC) was developed with the purpose of improving the solubility as well as the antifungal and antibiofilm activity of KET against Candida albicans. Results & methodology: The interactions among the components were studied using nuclear magnetic resonance, thermal analysis, powder x-ray diffraction, infrared spectroscopy and scanning electron microscopy. Phase-solubility studies demonstrated a considerable increase in the solubility of the MC. An enhancement in antibiofilm and antifungal activity of MC was determined against C. albicans by XTT assay and microbiological studies. Conclusion: This MC, with improvements in the drug pharmaceutical performance, might have an important potential in the development of new pharmaceutical formulations of KET.
