INVESTIGADORES
LONGHI Marcela Raquel
artículos
Título:
Investigating a Soluble Pharmaceutical Salt: Albendazole Hydrochloride
Autor/es:
BONGIOANNI, AGUSTINA; BUENO, MARIA SOLEDAD; ABRAHAM-MIRANDA, JULIETA; CHATTAH, ANA KARINA; AYALA, ALEJANDRO PEDRO; LONGHI, MARCELA RAQUEL; GARNERO, CLAUDIA
Revista:
CRYSTAL GROWTH & DESIGN
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2019 vol. 19 p. 4538 - 4545
ISSN:
1528-7483
Resumen:
: Albendazole is an effective antihelmintic drug,which has an unpredictable therapeutic response due to itslow solubility in biological fluids that limits its oral absorption.In an attempt to improve solubility, albendazole hydrochloride, a soluble pharmaceutical salt, was obtained andcharacterized by X-ray diffraction together with magic anglespinning solid-state nuclear magnetic resonance spectroscopy,Raman and Fourier transform infrared spectroscopies, thermalanalysis, energy-dispersive X-ray spectroscopy, and scanningelectron microscopy. These studies revealed that thecrystalline habit of albendazole hydrochloride is differentfrom that of the albendazole solid forms previously reported.The full structure was elucidated by performing single-crystalX-ray diffraction. The characterization studies showed the participation of the carbamate moiety in the salt formation. Inaddition, the solubility studies showed a significant increase in the solubility with respect to forms I and II of albendazole. Inconclusion, our results indicate that albendazole hydrochloride can be an auspicious salt to be used as a new product in anattempt to counteract unfavorable pharmaceutical properties