INVESTIGADORES
LONGHI Marcela Raquel
artículos
Título:
Intestinal uptake and toxicity evaluation of acetazolamide and its multicomponent complexes with hidroxypropyl-β-cyclodextrin in rats
Autor/es:
M. J. MORA; J. PETITI; M. LONGHI; A. TORRES; G. GRANERO
Revista:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 478 p. 258 - 267
ISSN:
0378-5173
Resumen:
Ternary complexes of acetazolamide (ACZ) with HP-B-CD in combination with triethanolamine (TEA) or calcium ions were found to provide an excellent approach that enabled an increased apparent permeability of ACZ across the duodenal epithelium, with a concomitant ability to preserve the integrity of gut epithelium from ACZ-induced injury. These results could be useful for the design and development of novel ACZ formulations that can reduce GI toxicity, while maintaining their essential therapeutic efficacies.
