INVESTIGADORES
LONGHI Marcela Raquel
artículos
Título:
Ternary Complexes of Flurbiprofen with HP-ß-CD a Ethanolamines. Characterization and Transdermal Delivery.
Autor/es:
MARCOS MAITRE, MARCELA LONGHI, GLADYS GRANERO
Revista:
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Editorial:
Taylor & Francis
Referencias:
Lugar: New York; Año: 2007 vol. 33 p. 311 - 326
ISSN:
0363-9045
Resumen:
Binary and multicomponent systems complexes prepared with HP-ß-CD and/or with monoethanolamine (MEA), diethanolamine (DEA) or triethanolamine (TEA) were obtained.
The results of solid-state studies indicated the presence of strong interactions between the components in the binary and the ternary systems. Drug solubility and dissolution rate in water were notably improved by employing the HP-ß-CD and the alkanolamines. The combined use of cosolvency and complexation with MEA in the presence of HP-ß-CD on the permeation of flurbiprofen through the human skin was evaluated. The combination of IPM, PG and HP-ß-CD yield the highest permeation for the flurbiprofen:MEA complex.
