INVESTIGADORES
VASCONSUELO Andrea Anahi
artículos
Título:
Actions of 17B- estradiol and testosterone in the mitochondria and their implications in aging
Autor/es:
ANDREA VASCONSUELO; LORENA MILANESI; RICARDO BOLAND
Revista:
AGEING RESEARCH REVIEWS
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Amsterdam; Año: 2013 p. 907 - 917
ISSN:
1568-1637
Resumen:
A decline in the mitochondrial functions and aging are two closely related processes. The presence of estrogen and androgen receptors and hormone-responsive elements in the mitochondria represents the starting point for the investigation of the effects of 17β-estradiol and testosterone on the mitochondrial functions and their relationships with aging. Both steroids trigger a complex molecular mechanism that involves crosstalk between the mitochondria, nucleus, and plasma membrane, and the cytoskeleton plays a key role in these interactions. The result of this signaling is mitochondrial protection. Therefore, the molecular components of the pathways activated by the sexual steroids could represent targets for anti-aging therapies. In this review, we discuss previous studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial processes implicated in aging.*(Corresponding author: Andrea Vasconsuelo)
