Layered double hydroxides such as an effectively reservoir for Indomethacin and Sodium Indomethacin

SILVIA MENDIETA; EMILIO NARDÓN; CELSO PÉREZ; SANDRA CASUSCELLI; GRISELDA EIMER; EDUARDO HERRERO; MÓNICA CRIVELLO

Córdoba

Encuentro; 1° Reunión Internacional de Ciencias Farmacéuticas.; 2010

<!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0pt; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 85.05pt 70.85pt 85.05pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> Layer double hydroxides (LDH) have been used as catalysts, ion exchangers, adsorbents(1-3). LDH of Mg-Al is biocompatible and has pharmaceutical applications, such as antacids, drug stabilizer, for the therapy of digestive disorders, and others(4). These materials consist of nano-layers of hydroxides, positively charged, and interlayer exchangeable anions. In the present work, Indomethacin (Indo) and Sodium Indomethacin (IndoNa) was incorporated into LDH Mg-Al-Cl by the anionic exchange method