Quercetin attenuates adipose inflammation/adiposity through activation of adipogenesis and angiogenesis

MIATELLO RM; PERDICARO DJ; OTEIZA P; RODRIGUEZ LANZI C; VAZQUEZ PRIETO MA

Simposio; II Simposio Internacional de Medicina Traslacional; 2019

Obesity is one of the main public health concerns worldwide. Increased adiposity, mainly visceral adipose tissue, is strongly associated with metabolic and cardiovascular disease among others. During excess of caloric intake, fat mass increases its size. It is well establish that adipocyte hypertrophy is a key characteristic of adipose tissue dysfunction. Adipocyte hypertrophy activate redox-signaling cascade leading to adipose dysfunction, inflammation and insulin resistance. Diet can play a major role in the prevention of obesity-associated pathologies. Flavonoids are the most abundant phenolic compounds in the plant kingdom with several health beneficial actions including antioxidant, anti-inflammatory, anti-carcinogenic effects among others. The flavonol quercetin (Q) is the main representative in plant foods, such as onions, broccoli, apples, tea and grapes. Q has been shown to have several health beneficial effects such as anti-inflammatory properties. We previously demonstrated that supplementation with grape pomace extract, rich in flavonoids compounds including Q, protect high-fat diet (HFD)-induced adipose hypertrophy and dysfunction in rats. Identify the active components that can provide protection against the adverse effects of consuming Western style diets has the potential to have a major impact on human health. In this study, we test the hypothesis that Q can stimulate a healthy adipose expansion promoting adipose angiogenesis and adipogenesis, reducing adipose hypertrophy, inflammation and activation of redox-sensitive signals in rats fed a HFD. The underlying protective action of Q and its main metabolites quercetin 3-glucuronide (G) was investigated in 3T3-L1 pre-adipocytes.