20 COMPARATIVE BEHAVIORAL EFFECTS OF CLORIMIPRAMINE AND REWARDING TREATMENTS IN AN ANIMAL MODEL OF DEPRESSION.

GARCÍA A, ADARO D, TORRECILLA M, RODRÍGUEZ ECHANDÍA E AND GONZÁLEZ JATUFF A.

Mendoza

Jornada; XXVIa Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2008

Sociedad de Biología de Cuyo

11   COMPARATIVE BEHAVIORAL EFFECTS OF CLORIMIPRAMINE AND REWARDING TREATMENTS IN AN ANIMAL MODEL OF DEPRESSION. García A, Adaro D, Torrecilla M, Rodríguez Echandía E and González Jatuff A. Biocell, Vol. 3 (1): pág A73 [N° 66] , 2009. Depression is a dissorder involving behavioral, neurochemical and emotional features. Though pharmacological treatments have proved to be effective in this syndrome, it is also known that reversal may also take place under non pharmacological schedules. In this work a comparisson between chlorimipramine (CIM, 3 mg/kg/day) and chronic aleatory rewarding (CAR), during 10 days, was made under basal conditions (B, Experiment 2) and after a chronic 14 day aleatory stress exposure (S, Experiment 1) in male rats, an animal model of depression used in previous works. In both S and CAR animals were exposed daily to different stressors or rewarders. 24 hs. after the antidepressant treatments, animals were observed in the following tests: 1.- OVM-holeboard, to test motor and exploratory activity. 2.- Plus-maze, to test pro-conflict (“ansiogenic”) performance. 3.- Forced swimming, to evaluate intra-stress reaction (scapes and inmobility). Animals were kept undisturbed for three weeks, and then challenged with a noise acute stress to evaluate motor and exploratory disruption-recovery in an enriched environment. During all the experiments sucaryl preference and corporal weight were recorded.  In S groups CIM showed Just after antidepressant treatments, CIM appeared to be more effective than