IMBECU 20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Nitric oxide bioavailability in hypertensive animal models: effect of (-)-epicatechin supplementation
Autor/es:
VALERIA CALABRÓ; BARBARA PIOTRKOWSKI; MARCELA VAZQUEZ-PRIETO; MÓNICA GALLEANO; CESAR G. FRAGA
Lugar:
Davis
Reunión:
Congreso; Oxidants and Antioxidants in Biology: Nutrition and Redox Biology in Development and Health; 2014
Institución organizadora:
Oxygen Club of California
Resumen:
This study evaluates the effects of dietary (-)-epicatechin (EC) supplementation on nitric oxide (NO) bioavailability in heart tissue, in two models of hypertension: i) rats deficient in NO by treatment with L-NAME, and ii) rats with metabolic syndrome (MetS) induced by consumption of a high fructose diet. In both models, EC prevented the hypertension-associated increases in: systolic blood pressure (SBP), GSSG/GSH2 and superoxide anion production and expression of p47phox NOX subunit (p
