Cardiac electrophysiological changes linked to vitamin d receptors deficiency

ALTAMIRANO L; DIEZ E; GARCÍA IM; MAZZEI LUCIANA; FERDER L; MANUCHA W

Potrero de los Funes. San Luis.

Jornada; XXX Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2012

Sociedad de Biología de Cuyo

Chronic kidney disease is highly prevalent and is associated with cardiovascular disease. Paricalcitol protects from some renal and cardiovascular complication. However, its electrophysiological effect during myocardial ischemia-reperfusion is currently unknown. Aims: Investigate in the ON model, potential structural and functional changes of the heart linked to vitamin D deficiency. Methods: Adult rats (n=10) were unilaterally obstructed at the uretero-pelvic level. An inductor of vitamin D receptor (VDR) was administered for 15 days IP (30ng/Kg/day). We evaluated histological, molecular and biochemical parameters, as well, cardiac electrophysiological activity with ischemia-reperfusion protocol. Results: we found changes in action potential duration (APD) at 90% (* P