Premio Jenny Pronczuk al mejor trabajo completo. Otorgado por el Colegium Ramazzini y el Departamento de Toxicología y el Departamento de Salud Ocupacional del Hospital de Clínicas. Facultad de Medicina, U de la República en la Conferencia Internacional

ROVEDATTI MARÍA GABRIELA; GUIÑAZÚ NATALIA; BULGARONI VANINA; ALVAREZ GABRIEL; CHIAPELLA GRACIELA; VERA BERTA; QUINTANA MARÍA MARTHA; RIVERO VALERIA; SABINO GUILLERMO; QUIDEL NATALIA; ANDERLE SOFÍA; BERTONE MARÍA CECILIA; VALDEZ SUSANA R; MAGNARELLI GLADIS

Montevideo

Conferencia; Conferencia Internacional Salud Ambiental en la Agenda Política; 2012

Departamento de Toxicología -UDELAR

Premio Jenny Pronczuk al mejor trabajo completo. Otorgado por el Colegium Ramazzini y el  Departamento de Toxicología y el Departamento de Salud Ocupacional del Hospital de Clínicas. Facultad de Medicina, U de la República en la Conferencia Internacional Salud Ambiental en la Agenda Política. IMPACT OF PESTICIDE ENVIRONMETAL EXPOSURE IN THE TRIAD MOTHER-PLACENTA-FETUS AND PREVENTIVE ACTIONSMaría Gabriela Rovedatti1, Natalia Guiñazu1, Vanina Bulgaroni1, Gabriel Alvarez2,3, Amalia Cecchi 4, Graciela Chiapella1,2, Berta Vera1,2, María Martha Quintana1, Valeria Rivero1, Guillermo Sabino5, Natalia Quidel 2, Sofia Anderle2, María Cecilia Bertone2, Susana R Valdez 6 y Gladis Magnarelli* 1,21. IDEPA-CONICET. Universidad Nacional del Comahue (UNCo), Buenos Aires 1400 (8300) Neuquén, Argentina.2. Facultad de Ciencias Médicas, UNCo.3. Hospital Castro Rendón, Neuquén.4. Hospital E. Accame, Allen, Río Negro.5. Facultad de Economía y Administración UNCo.6. IMBECU-CCT Mendoza, Instituto de Ciencias Básicas, Universidad Nacional de Cuyo* E-mail: ggmagnarelli @yahoo.com.ar ABSTRACTConsidering that perinatal health represents a relevant public health problem, this work studied the environmental exposure to pesticides in the Upper Valley of Río Negro and Neuquén, Argentina, where organophosphates (OP), are intensively used. We performed a prospective study with 776 pregnant women, using inclusion/exclusion criteria. The goal of this workwas to identify changes in effect biomarkers in the triad mother-placenta-fetus, the mechanisms involved and their association with intrauterine development. Biochemical, molecular and morphometric parameters in the rural population (PoR) in pulverization (PP) and pre-pulverization periods (PreP) and in the control group of urban residence (PoU) wereanalysed. Pregnancy alterations were also recorded. According to blood cholynesterases we stablished that PoR pregnant women were exposed to OP and also presented endocrine disruption (alterations in cortisol and progesterone levels). In the placenta we observed modifications in carboxylesterase activity, mitochondrial enzyme activities, progesterone levels and in the expression of cytokines (IL-13, TGFβ and TNFα). Umbilical cord blood preliminary results suggest an adaptive response to oxidative stress in erythrocyte and augmented rate of genetic damage in lymphocytes. Taking into account confounding factors, height and head circumference (adjusted by neonate sex and gestational age) were lower in PoR than PoU, while the percentage of newborns with head circumference below the 5th percentile was higher. In PoR a higher percentage of threatened abortion was recorded. These findings suggest association between pesticide exposure and changes in the intrauterine development, with possible short and long term health consequences. Additionally, preventive educational actions were carried out at public hospitals and schools in order to minimize the risk of pesticides exposure in vulnerable groups.Key words: pesticides, pregnancy, newborn, environmental exposure, risk prevention.