Excreción urinaria de albúmina (EUA) post ejercicio intenso y prolongado en runners con Diabetes Mellitus tipo 1

MINUCHIN, GABRIEL; CEJAS, JIMENA; ESTEVES,GUILLERMO; RODRIGUEZ-VITORIA, JUAN; CRUZADO MONTSERRAT; CASTRO, CLAUDIA; RODRIGUEZ, GUILLERMO MARTIN

Mendoza

Jornada; IV Jornadas Regionales de Diabetes en Otoño; 2012

Sociedad Argentina de Diabetes

Background and aims: Previous studies indicate that in patients with normotensive and normoalbuminuric type 1 diabetes (DM1) there is a shortly transient elevation of urinary albumin excretion (UAE), expressed as albumin/creatinine ratio (A/C), after intense exercise of moderate length, returning to normal values the next morning. Studies that assess the impact of prolonged intense exercise on the ratio A/C in normoalbuminuric type 1 diabetic runners is lacking. With the aim of evaluate the UAE in DM1 marathoners, we conducted 2 experiments. We first measured the UAE in 5 normotensive normoalbuminuric runners with type 1 diabetes, before and 24 hours after running a whole marathon (42,195 km). Then, we evaluated in 6 normoalbuminuric and normotensive patients DM1, the ratio A/C at the beginning, ending and after 24 h of running a half marathon (21.1 miles), and compared with 6 controls non DM1 runners. Statistical comparisons were performed using a paired Student's t test with significance set at P < 0.05. Conclusions: In normotensive and normoalbuminuric DM1 and non DM1 runners, intense and prolonged exercise like running a marathon (42.195 km) or a half marathon (21.1 km), provoked a significant transient increase of UAE which returned to normal values immediately after exercise. Noteworthy, the elevation of UAE immediately post exercise, was significantly higher in DM1 runners.