Vascular Repair and Remodeling: A Review

NICOLÁS RENNA; ROBERTO MIATELLO; JÉSICA RAMÍREZ; RODRIGO GARCÍA

Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy

InTech

Lugar: Clemson SC, USA; Año: 2017; p. 195 - 212

Atherosclerotic narrowing of the arterial lumen is not simply the result of the enlargement of atherosclerotic lesions. Instead of creating a lumen by remodeling the arterial narrowing, arteries undergo changes, such as increasing the outer diameter, allowing the preservation of blood flow. This adaptability is essential in most arterial diseases. Diseases such as arterial hypertension may be considered failures of the arterial wall to maintain a suitable mesh size to allow normal blood flow. Recently, it has been suggested that the inability to remodel vessels properly is a way of "vascular insufficiency", similar to that observed in the heart during heart failure.Vascular wall remodeling is the result of changes in cellular and non-cellular components, depending on the disease process causing the changes. Changes in the growth and migration of VSMC, endothelial dysfunction, inflammatory processes, and the synthesis or degradation of extracellular matrix components may be present during the disease process.