IMBECU 20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
artículos
Título:
Systemically administered allogeneic mesenchymal stem cells do not aggravate the progression of precancerous lesions: a new biosafety insight
Autor/es:
ESPINOZA, IRIS; BRUNA, FLAVIA; CONGET, PAULETTE; PLAZA, ANITA; ARANGO, MARTHA
Revista:
Stem Cell Research & Therapy
Editorial:
Springer Nature
Referencias:
Lugar: Londres; Año: 2018 vol. 9
Resumen:
Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and to suppress immune response raises questions regarding their biosafety. Our aim was to evaluate whether systemically administered allogeneic MSCs modify the natural progression of precancerous lesions and whether their putative effect depends on cancer stage and/or cell dose.
