ADIPONECTIN IN PEDIATRIC PERITONEAL DIALYSIS. RELATIONSHIP TO INSULIN RESISTANCE AND NUTRITIONAL STATUS

MARIANA KAMARISKI; MÓNICA BISCARDI; LAURA CESTINO; ROBERTO MIATELLO; ENRIQUE GUNTSCHE; PATRICIA G VALLÉS

NEPHRON

Karger

Lugar: London; Año: 2008

0028-2766

Aim: To study whether adiponectin and resistin serum concentrations in peritoneal dialysis (PD) pediatric patients were related with insulin resistance and anthropometric parameters of nutritional status, 11 PD patients, 9 CKD patients and 10 healthy children were studied. Methods: Glucose and insulin were measured during oral glucose tolerance test. Levels of adiponectin and resistin were evaluated by ELISA, insulin by RIA. Results: In CKD patients, higher HOMA-IR, fasting and 2h serum insulin levels were shown compared to control and to PD patients. Body mass index (BMI) and body fat content were severely decreased while serum adiponectin levels were significantly higher in PD patients relative to controls. No differences among groups were shown in resistin levels. On regression modelling, inverse independent associations were observed between adiponectin with percentile BMI, weight and height z-score, and with body fat content. In contrast, no relationship was found between adiponectin and insulin resistance parameters. In multiple regression analysis, adiponectin was significantly negatively correlated with BMI. A negative association of adiponectin  and resistin with GFR was shown. Conclusion: For these results, absence of insulin resistance was demonstrated in PD patients. A role of adiponectin in terms of its association to clinical wasting parameters in peritoneal dialysis pediatric patients, might be suggested.