Enterococcus durans EP1 modulates inflammation in a DSS-induced colitis model in mice

CARASI P; RACEDO S; JACQUOT C; SERRADELL MA; URDACI MC

Milán

Congreso; 15th International Congress of Immunology; 2013

International Union of Immunology Societies (IUIS)

Enterococcus durans EP1 is gram-positive coccus that has shown certain probiotic properties. The objective of this work was to evaluate the immunomodulatory capacity of EP1 in a colitis model induced by dextran sulfate sodium (DSS) in mice. Six weeks old Swiss mice were separated in two groups of 16 animals. During 14 days, one group received daily 108 cfu/mice of EP1 and the other received PBS. On day 14, each of the mentioned groups was separated in two (eight mice each) and administration of DSS 3%w/v started for one of them and lasted seven days. At the end of the experimental protocol,significant differences in the disease activity index were observed between DSS group and DSS treated with EP1 mice (DSS-EP1), DSS mice´s colons were shorter (p