INVESTIGADORES
ORELLI Liliana Raquel
artículos
Título:
A new procedure for Horner-Wadsworth-Emmons olefination of carbonyl compounds
Autor/es:
FRANCESCO BONADIES; ANTONELLA CARDILLI; ALESSANDRA LATTANZI; LILIANA R. ORELLI; ARRIGO SCETTRI
Revista:
TETRAHEDRON LETTERS
Editorial:
Elsevier
Referencias:
Año: 1994 vol. 35 p. 3383 - 3386
ISSN:
0040-4039
Resumen:
Aliphatic and aromatic aldehydes undergo an efficient E-stereoselective Horner-Wadsworth-Emmons olefination with triethylphosphonacetates, by generation of phosphonate carbanion with LiOH. The reaction also proceeds satisfactorily with linear, cyclic and a,b-unsaturated ketones in the presence of activated zeolites, with slow addition of the base. This methodology proved to be compatible with the presence of additional functional groups in the carbonyl compound such as acetals, esters and halogens.
