INVESTIGADORES
CESANI ROSSI Maria Florencia
congresos y reuniones científicas
Título:
Association between genetic profile assessed from 10 SNPs (single nucleotide polymorphisms) and anthropometric obesity in argentine schoolchildren
Autor/es:
ALAMINOS TORRES, A; NAVAZO B; MARRODÁN MD; LOPEZ EJEDA M; GARRAZA M; GAUNA ME; TORRES MF; CESANI MF
Lugar:
Denver
Reunión:
Congreso; 47thAnnual Meeting of the Human Biology Association; 2022
Institución organizadora:
Human Biology Association
Resumen:
Data were collected in 2019 in the city of La Plata, Buenos Aires province. Height, weight, body circunferences and subcutaneous skinfolds were measured, estimating body mass index (BMI), waist-to-height ratio (WtHR), and body fat percentage (%BF). DNA was isolated from saliva and 10 single base polymorphisms (SPNs) in the TMEM18, INSIG2, GNPDA2, CLOCK, FAM120AOS, FAIM2, OLFM4 and FTO genes (rs1558902, rs171817449, rs9939609) were genotyped. The nutritional phenotype-genotype association was analysed for each of the SNPs separately and with the genetic risk score (GR) set at a range between 0 (no risk allele) and 20 points (homozygous risk for all 10 markers). A GR score above the 50th percentile (4.96 ± 2.48) was associated with increased waist circumference, skinfold sum, BMI, %BFG and WtHR. Anthropometric indicators showed higher prevalences according to polygenic risk, with significant differences between Q1 and Q4 for excess weight (29.10% vs 44.30%), high adiposity (17.30% vs 30.10%) and abdominal obesity (41.19% vs 54.90%).