Strategies for Solving the Synthesis Problem in Multiproduct Batch Protein Production Processes

A. R. VECCHIETTI; J.M. MONTAGNA; O.A. IRIBARREN

Foundations of Computer-Aided Process Operations (FOCAPO 2003)

CACHE Publications

Año: 2003; p. 493 - 497

This paper deals with the synthesis and design of a multiproduct batch protein production processes. Four products and at most 15 batch stages are involved in the plant synthesis and design. Constant size and time factors are used for the design constraints. The host, batch stages and type of unit operating in some of the stages are discrete decisions included in the model. A disjunctive model has been formulated for the problem. The model solution has been performed transforming the disjunctive model into Mixed Integer Nonlinear Programs (MINLP) using the Big-M and convex-hull relaxations of a disjunctive set. The results obtained and the behavior of both MINLÐ models used to solve the problem is shown.