A possible inhibitory action of baclofen on hippocampus gabaergic neurones.

BALERIO G. N., OTERO LOSADA M. AND RUBIO M. C.

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM

Año: 1994 vol. 25 p. 297 - 301

0306-3623

1. The function of the gamma-aminobutyric acid (GABA)ergic system in certain areas of the rat brain was investigated after baclofen treatment (30 mg/kg for 4 days). 2. Two h after the last dose of baclofen GAD activity was reduced in the hippocampus without changes in GABA levels. 24 h after baclofen, GAD activity was increased and the GABA content was decreased. 3. 48 h after the last dose both parameters returned to control values. 4. These results were not observed in any of the other areas investigated: frontal cerebral cortex, corpus striatum, olfactory bulbs, and medio basal hypothalamus. 5. In conclusion, the present study shows that baclofen 30 mg/kg for 4 days, induces an inhibitory action on hippocampus GABAergic neurones, which begins to disappear after 24 h free of drug.