INVESTIGADORES
BUSTAMANTE Ana Victoria
artículos
Título:
GeneticcharacterizationofShigatoxin-producingEscherichiacoliO26:H11strainsisolatedfromanimal,food,andclinicalsamples
Autor/es:
KRUGER, A; LUCCHESI P.M. A.; AM SANSO; A. V. BUSTAMANTE; BURGAN JULIA; FERNANDEZ LUCIANA; ETCHEVERRIA AI; FERNÁNDEZ, D; LEOTTA GERARDO; FRIEDRICH ALEXANDER; PADOLA N. L; ROSSEN J
Revista:
frontiers in cellular and infection microbiology
Editorial:
frontiers
Referencias:
Lugar: texas; Año: 2015 vol. 5 p. 1 - 8
ISSN:
2235-2988
Resumen:
TheShiga-toxinproducingEscherichiacoli(STEC)maycauseseriousillnessinhuman.HereweanalyzeO26:H11strainsknowntobeamongthemostreportedSTECstrainscausinghumaninfections.Geneticcharacterizationofstrainsisolatedfromanimal,food,andclinicalspecimensinArgentinashowedthatmostcarriedeitherstx1aorstx2asubtypes.Interestingly,stx2a-positiveO26:H11rarelyisolatedfromcattleinothercountriesshowedtobeanimportantproportionofO26:H11strainscirculatingincattleandfoodinourregion.Seventeenpercentoftheisolatesharboredmorethanonegeneassociatedwithantimicrobialresistance.Inadditiontostx,allstrainscontainedthevirulencegeneseae-b,tir,efa,iha,espB,cif,espA,espF,espJ,nleA,nleB,nleC,andiss;andallexceptonecontainedehxA,espP,andcbagenes.Ontheotherhand,toxBandespIgeneswereexclusivelyobservedinstx2-positiveisolates,whereaskatPwasonlyfoundinstx1a-positiveisolates.OurresultsshowthatO26:H11STECstrainscirculatinginArgentina,includingthoseisolatedfromhumans,cattle,andmeatproducts,presentahighpathogenicpotential,andevidencethatcattlecanbeareservoirofO26:H11strainsharboringstx2a.
